Interproximal reduction (IPR) involves the selective removal of enamel proximally to create space for tooth movement. IPR can be performed in conjunction with traditional orthodontics or clear aligners, with treatment planned by the clinician or, in some cases, through lab services that utilize digital technology. IPR is a safe and effective method to create space for orthodontic tooth movement where mild or moderate crowding exists, particularly useful for treating crowding in the anterior segment (the ‘social six’) and suitable for recontouring individual teeth.